Gentowa

The skin tests are necessary supplements of all basic allergist examinations. The allergichypersensitiveness proof was discovered by Charlie Blackley already in 1865. The techniquewas later on improved by Grant Lewis, Pepyes and others, who introduced the prick test (stinger) usage. Nowadays the standardized method introduced by the European allergist andclinical immunology academy. The skin test in based on the fact, that sensitive allergic patient has specific antibodiesagainst the allergens not only in the particular organ, in which the clinical symptoms areactive, but also in the cell membrane – mastocyte which are in the skin.

While testing, the suspect allergen is injected into the patients´ skin near the forearm.

 The allergen choice is made according to the patients´ data on the clinical symptoms period.

The standard group of allergens, which includes the following, is used:

 ● trees pollen

● grass pollen

● rye

● worm wood

● ambrosia

● mould

● feather

● mites

● positive control (histamine)

●negative control (usually a solution with dissolved allergens)

According to the seasonality, others allergens are added. If the patient is in the contactwith the animals, the animal allergens (dog, cat, etc) are tested, as well. Before the testing thepatient should cease the anti allergic treatment (the antihistamines for at least one week), butothers, as well. For example many preparations used by the psychiatrists relieve even the skin reaction at the skin tests.

When possible, the patient should be tested even off pollen season. It is notappropriate to test somebody during or right after the infection since it can cover the reaction,as well.

For checking the skin test realisation correctness beside the allergens, the positive andthe negative control is injected. As the positive control histamine is used – a chemical, whichis released during the allergic reaction in general, i.e. test with this chemical can be positiveeven in the case of the health people. If this reaction after the testing is negative, the test is notvalid, since some of the processes or the medications relieved all reactions.The negative checking is, on the contrary, is injected in order to exclude the reaction,which is only mechanical – the injury or the injection itself, or the allergic reaction to thesolution, eventually to the conservative chemical in the allergen solution.

The skin tests allergens are made commercially. Their content and dilution are standardised.